Publication Abstract from PubMed
A series of 3,4,5-trisubstituted 1,2,4-4H triazole derivatives was synthesized and investigated for HIV-1 reverse transcriptase inhibition. An X-ray structure with HIV-1 RT secured the binding mode and allowed the key interactions with the enzyme to be identified.
Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase--structure-activity relationships and crystallographic analysis.,Kirschberg TA, Balakrishnan M, Huang W, Hluhanich R, Kutty N, Liclican AC, McColl DJ, Squires NH, Lansdon EB Bioorg Med Chem Lett. 2008 Feb 1;18(3):1131-4. Epub 2007 Dec 5. PMID:18083512[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
