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3d3t
From Proteopedia
Revision as of 07:41, 29 September 2014 by OCA (Talk | contribs)
3d3t is a 3 chain structure with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The effect of amino acid variability between human immunodeficiency virus type 1 (HIV-1) clades on structure and the emergence of resistance mutations in HIV-1 protease has become an area of significant interest in recent years. We determined the first crystal structure of the HIV-1 CRF01_AE protease in complex with the p1-p6 substrate to a resolution of 2.8 A. Hydrogen bonding between the flap hinge and the protease core regions shows significant structural rearrangements in CRF01_AE protease compared to the clade B protease structure.
Structural analysis of human immunodeficiency virus type 1 CRF01_AE protease in complex with the substrate p1-p6.,Bandaranayake RM, Prabu-Jeyabalan M, Kakizawa J, Sugiura W, Schiffer CA J Virol. 2008 Jul;82(13):6762-6. Epub 2008 Apr 23. PMID:18434392[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Bandaranayake RM, Prabu-Jeyabalan M, Kakizawa J, Sugiura W, Schiffer CA. Structural analysis of human immunodeficiency virus type 1 CRF01_AE protease in complex with the substrate p1-p6. J Virol. 2008 Jul;82(13):6762-6. Epub 2008 Apr 23. PMID:18434392 doi:10.1128/JVI.00018-08
