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2f16
From Proteopedia
Revision as of 09:27, 29 September 2014 by OCA (Talk | contribs)
2f16 is a 28 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The dipeptide boronic acid bortezomib, also termed VELCADE, is a proteasome inhibitor now in use for the treatment of multiple myeloma, and its use for the treatment of other malignancies is being explored. We determined the crystal structure of the yeast 20S proteasome in complex with bortezomib to establish the specificity and binding mode of bortezomib to the proteasome's different catalytically active sites. This structure should enable the rational design of new boronic acid derivatives with improved affinities and specificities for individual active subunits.
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.,Groll M, Berkers CR, Ploegh HL, Ovaa H Structure. 2006 Mar;14(3):451-6. PMID:16531229[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Groll M, Berkers CR, Ploegh HL, Ovaa H. Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome. Structure. 2006 Mar;14(3):451-6. PMID:16531229 doi:10.1016/j.str.2005.11.019
