| Structural highlights
2ow8 is a 23 chain structure with sequence from Escherichia coli and Thermus thermophilus. This structure supersedes the now removed PDB entry 2i1c. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | NonStd Res: | , , , , , , , , , , , |
| Related: | 1gix, 1giy, 1vsa |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Our understanding of the mechanism of protein synthesis has undergone rapid progress in recent years as a result of low-resolution X-ray and cryo-EM structures of ribosome functional complexes and high-resolution structures of ribosomal subunits and vacant ribosomes. Here, we present the crystal structure of the Thermus thermophilus 70S ribosome containing a model mRNA and two tRNAs at 3.7 A resolution. Many structural details of the interactions between the ribosome, tRNA, and mRNA in the P and E sites and the ways in which tRNA structure is distorted by its interactions with the ribosome are seen. Differences between the conformations of vacant and tRNA-bound 70S ribosomes suggest an induced fit of the ribosome structure in response to tRNA binding, including significant changes in the peptidyl-transferase catalytic site.
Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements.,Korostelev A, Trakhanov S, Laurberg M, Noller HF Cell. 2006 Sep 22;126(6):1065-77. Epub 2006 Sep 7. PMID:16962654[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Korostelev A, Trakhanov S, Laurberg M, Noller HF. Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements. Cell. 2006 Sep 22;126(6):1065-77. Epub 2006 Sep 7. PMID:16962654 doi:http://dx.doi.org/10.1016/j.cell.2006.08.032
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