Publication Abstract from PubMed
A novel series of inhibitors for mitogen activated protein kinase-activated protein kinase 2 (MK-2) are reported. These squarate based inhibitors were identified via a high-throughput screen. An MK2 co-structure with the starting ligand was obtained and a structure based approach was followed to optimize potency and selectivity.
Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).,Lovering F, Kirincich S, Wang W, Combs K, Resnick L, Sabalski JE, Butera J, Liu J, Parris K, Telliez JB Bioorg Med Chem. 2009 May 1;17(9):3342-51. Epub 2009 Mar 26. PMID:19364658[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
