Publication Abstract from PubMed
The crystal structure of a host defense system chemotactic factor, interleukin 8, has been solved by molecular replacement using as a model the solution structure derived from nuclear magnetic resonance experiments. The structure was refined with 2 A x-ray data to an R factor of 0.187 (0.217 at 1.6 A). A comparison indicates some potential differences between the structure in solution and in the crystalline state. Our analysis also predicts that residues 4 through 9 on the amino terminus and the beta-bend, which includes His-33, may be important for receptor binding.
Crystal structure of interleukin 8: symbiosis of NMR and crystallography.,Baldwin ET, Weber IT, St Charles R, Xuan JC, Appella E, Yamada M, Matsushima K, Edwards BF, Clore GM, Gronenborn AM, et al. Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):502-6. PMID:1988949[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
