1gqe

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Image:1gqe.gif


PDB ID 1gqe

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, resolution 1.81Å
Coordinates: save as pdb, mmCIF, xml



POLYPEPTIDE CHAIN RELEASE FACTOR 2 (RF2) FROM ESCHERICHIA COLI


Overview

Bacterial release factor RF2 promotes termination of protein synthesis, specifically recognizing stop codons UAA or UGA. The crystal structure of Escherichia coli RF2 has been determined to a resolution of 1.8 A. RF2 is structurally distinct from its eukaryotic counterpart eRF1. The tripeptide SPF motif, thought to confer RF2 stop codon specificity, and the universally conserved GGQ motif, proposed to be involved with the peptidyl transferase center, are exposed in loops only 23 A apart, and the structure suggests that stop signal recognition is more complex than generally believed.

About this Structure

1GQE is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Bacterial polypeptide release factor RF2 is structurally distinct from eukaryotic eRF1., Vestergaard B, Van LB, Andersen GR, Nyborg J, Buckingham RH, Kjeldgaard M, Mol Cell. 2001 Dec;8(6):1375-82. PMID:11779511

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