Publication Abstract from PubMed
A novel series of 1H-indol-1-yl tertiary amine LXR agonists has been designed. Compounds from this series were potent agonists with good rat pharmacokinetic parameters. In addition, the crystal structure of an LXR agonist bound to LXRalpha will be disclosed.
Synthesis and SAR of potent LXR agonists containing an indole pharmacophore.,Washburn DG, Hoang TH, Campobasso N, Smallwood A, Parks DJ, Webb CL, Frank KA, Nord M, Duraiswami C, Evans C, Jaye M, Thompson SK Bioorg Med Chem Lett. 2009 Jan 9. PMID:19167885[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
