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1sig
From Proteopedia
Revision as of 15:08, 29 September 2014 by OCA (Talk | contribs)
1sig is a 1 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The 2.6 A crystal structure of a fragment of the sigma 70 promoter specificity subunit of E. coli RNA polymerase is described. Residues involved in core RNA polymerase binding lie on one face of the structure. On the opposite face, aligned along one helix, are exposed residues that interact with the -10 consensus promoter element (the Pribnow box), including four aromatic residues involved in promoter melting. The structure suggests one way in which DNA interactions may be inhibited in the absence of RNA polymerase and provides a framework for the interpretation of a large number of genetic and biochemical analyses.
Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase.,Malhotra A, Severinova E, Darst SA Cell. 1996 Oct 4;87(1):127-36. PMID:8858155[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Malhotra A, Severinova E, Darst SA. Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase. Cell. 1996 Oct 4;87(1):127-36. PMID:8858155
