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1svb
From Proteopedia
Revision as of 16:15, 29 September 2014 by OCA (Talk | contribs)
1svb is a 1 chain structure with sequence from Tick-borne encephalitis virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The crystallographically determined structure of a soluble fragment from the major envelope protein of a flavivirus reveals an unusual architecture. The flat, elongated dimer extends in a direction that would be parallel to the viral membrane. Residues that influence binding of monoclonal antibodies lie on the outward-facing surface of the protein. The clustering of mutations that affect virulence in various flaviviruses indicates a possible receptor binding site and, together with other mutational and biochemical data, suggests a picture for the fusion-activating, conformational change triggered by low pH.
The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution.,Rey FA, Heinz FX, Mandl C, Kunz C, Harrison SC Nature. 1995 May 25;375(6529):291-8. PMID:7753193[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Rey FA, Heinz FX, Mandl C, Kunz C, Harrison SC. The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution. Nature. 1995 May 25;375(6529):291-8. PMID:7753193 doi:http://dx.doi.org/10.1038/375291a0
