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2j7o

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Revision as of 15:21, 30 October 2007 by OCA (Talk | contribs)
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Image:2j7o.gif

2j7o, resolution 3.5Å

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STRUCTURE OF THE RNAI POLYMERASE FROM NEUROSPORA CRASSA

Overview

RNA silencing refers to a group of RNA-induced gene-silencing mechanisms, that developed early in the eukaryotic lineage, probably for defence, against pathogens and regulation of gene expression. In plants, protozoa, fungi, and nematodes, but apparently not insects and vertebrates, it, involves a cell-encoded RNA-dependent RNA polymerase (cRdRP) that produces, double-stranded RNA triggers from aberrant single-stranded RNA. We report, the 2.3-A resolution crystal structure of QDE-1, a cRdRP from Neurospora, crassa, and find that it forms a relatively compact dimeric molecule, each, subunit of which comprises several domains with, at its core, a catalytic, apparatus and protein fold strikingly similar to the catalytic core of the, DNA-dependent RNA polymerases responsible for ... [(full description)]

About this Structure

2J7O is a [Single protein] structure of sequence from [Neurospora crassa] with MG as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

The structure of an RNAi polymerase links RNA silencing and transcription., Salgado PS, Koivunen MR, Makeyev EV, Bamford DH, Stuart DI, Grimes JM, PLoS Biol. 2006 Dec;4(12):e434. PMID:17147473

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