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1h6i

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Revision as of 09:32, 20 March 2008 by OCA (Talk | contribs)
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Image:1h6i.gif


PDB ID 1h6i

Drag the structure with the mouse to rotate
, resolution 3.54Å
Coordinates: save as pdb, mmCIF, xml



A REFINED STRUCTURE OF HUMAN AQUAPORIN 1


Contents

Overview

A refined structure of the human water channel aquaporin-1 is presented. The model rests on the high resolution X-ray structure of the homologous bacterial glycerol transporter GlpF, electron crystallographic data at 3.8 A resolution and a multiple sequence alignment of the aquaporin superfamily. The crystallographic R and free R values (36.7% and 37.8%) for the refined structure are significantly lower than for previous models. Improved geometry and enhanced stability in molecular dynamics simulations demonstrate a significant improvement of the aquaporin-1 structure. Comparison with previous aquaporin-1 models shows significant differences, not only in the loop regions, but also in the core of the water channel.

Disease

Known diseases associated with this structure: Aquaporin-1 deficiency OMIM:[107776], Blood group, Colton OMIM:[107776]

About this Structure

1H6I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A refined structure of human aquaporin-1., de Groot BL, Engel A, Grubmuller H, FEBS Lett. 2001 Aug 31;504(3):206-11. PMID:11532455

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