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1tf6
From Proteopedia
Revision as of 19:02, 29 September 2014 by OCA (Talk | contribs)
1tf6 is a 6 chain structure with sequence from Xenopus laevis. The March 2007 RCSB PDB Molecule of the Month feature on Zinc Fingers by David S. Goodsell is 10.2210/rcsb_pdb/mom_2007_3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The crystal structure of the six NH2-terminal zinc fingers of Xenopus laevis transcription factor IIIA (TFIIIA) bound with 31 bp of the 5S rRNA gene promoter has been determined at 3.1 A resolution. Individual zinc fingers are positioned differently in the major groove and across the minor groove of DNA to span the entire length of the duplex. These results show how TFIIIA can recognize several separated DNA sequences by using fewer fingers than necessary for continuous winding in the major groove.
Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex.,Nolte RT, Conlin RM, Harrison SC, Brown RS Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2938-43. PMID:9501194[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Nolte RT, Conlin RM, Harrison SC, Brown RS. Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2938-43. PMID:9501194
