This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2j8x

From Proteopedia

Revision as of 15:22, 30 October 2007 by OCA (Talk | contribs)
Jump to: navigation, search
Image:2j8x.gif

2j8x, resolution 2.30Å

Drag the structure with the mouse to rotate

EPSTEIN-BARR VIRUS URACIL-DNA GLYCOSYLASE IN COMPLEX WITH UGI FROM PBS-2

Overview

Epstein-Barr virus (EBV) is a human gamma-herpesvirus. Within its 86 open, reading frame containing genome, two enzymes avoiding uracil incorporation, into DNA can be found: uracil triphosphate hydrolase and uracil-DNA, glycosylase (UNG). The latter one excises uracil bases that are due to, cytosine deamination or uracil misincorporation from double-stranded DNA, substrates. The EBV enzyme belongs to family 1 UNGs. We solved the, three-dimensional structure of EBV UNG in complex with the uracil-DNA, glycosylase inhibitor protein (Ugi) from bacteriophage PBS-2 at a, resolution of 2.3 A by X-ray crystallography. The structure of EBV UNG, encoded by the BKRF3 reading frame shows the excellent global structural, conservation within the solved examples of family 1 enzymes. Four out of, the ... [(full description)]

About this Structure

2J8X is a [Protein complex] structure of sequences from [Human herpesvirus 4] and [Phage pbs1] with URE as [ligand]. Active as [Uridine nucleosidase], with EC number [3.2.2.3]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

New insights on the role of the gamma-herpesvirus uracil-DNA glycosylase leucine loop revealed by the structure of the Epstein-Barr virus enzyme in complex with an inhibitor protein., Geoui T, Buisson M, Tarbouriech N, Burmeister WP, J Mol Biol. 2007 Feb 9;366(1):117-31. Epub 2006 Nov 7. PMID:17157317

Page seeded by OCA on Tue Oct 30 17:27:17 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2j8x"
Personal tools