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1tvt
From Proteopedia
Revision as of 20:56, 29 September 2014 by OCA (Talk | contribs)
1tvt is a 1 chain structure with sequence from Equine infectious anemia virus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Trans-activator (Tat) proteins regulate the transcription of lentiviral DNA in the host cell genome. These RNA binding proteins participate in the life cycle of all known lentiviruses, such as the human immunodeficiency viruses (HIV) or the equine infectious anemia virus (EIAV). The consensus RNA binding motifs [the trans-activation responsive element (TAR)] of HIV-1 as well as EIAV Tat proteins are well characterized. The structure of the 75-amino acid EIAV Tat protein in solution was determined by two- and three-dimensional nuclear magnetic resonance methods and molecular dynamics calculations. The protein structure exhibits a well-defined hydrophobic core of 15 amino acids that serves as a scaffold for two flexible domains corresponding to the NH2- and COOH-terminal regions. The core region is a strictly conserved sequence region among the known Tat proteins. The structural data can be used to explain several of the observed features of Tat proteins.
Structure of the equine infectious anemia virus Tat protein.,Willbold D, Rosin-Arbesfeld R, Sticht H, Frank R, Rosch P Science. 1994 Jun 10;264(5165):1584-7. PMID:7515512[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Willbold D, Rosin-Arbesfeld R, Sticht H, Frank R, Rosch P. Structure of the equine infectious anemia virus Tat protein. Science. 1994 Jun 10;264(5165):1584-7. PMID:7515512
