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2bai
From Proteopedia
Revision as of 00:29, 30 September 2014 by OCA (Talk | contribs)
2bai is a 1 chain structure with sequence from Mengo virus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The Leader protein is a defining feature of picornaviruses from the Cardiovirus genus. This protein was recently shown to inhibit cellular nucleocytoplasmic transport through an activity mapped to its zinc-binding region. Here we report the three-dimensional solution structure determined by nuclear magnetic resonance (NMR) spectroscopy of this domain (residues 5-28) from mengovirus. The domain forms a CHCC zinc-finger with a fold comprising a beta-hairpin followed by a short alpha-helix that can adopt two different conformations. This structure is divergent from those of other eukaryotic zinc-fingers and instead resembles motifs found in a group of DNA-binding proteins from Archaea.
NMR structure of the mengovirus Leader protein zinc-finger domain.,Cornilescu CC, Porter FW, Zhao KQ, Palmenberg AC, Markley JL FEBS Lett. 2008 Mar 19;582(6):896-900. Epub 2008 Feb 20. PMID:18291103[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
