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2dok
From Proteopedia
Revision as of 03:02, 30 September 2014 by OCA (Talk | contribs)
2dok is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Saccharomyces cerevisiae Est1p is a telomerase-associated protein essential for telomere length homeostasis. hEST1A is one of the three human Est1p homologues and is considered to be involved not only in regulation of telomere elongation or capping but also in nonsense-mediated degradation of RNA. hEST1A is composed of two conserved regions, Est1p homology and PIN (PilT N-terminus) domains. The present study shows the crystal structure of the PIN domain at 1.8 A resolution. The overall structure is composed of an alpha/beta fold or a core structure similar to the counterpart of 5' nucleases and an extended structure absent from archaeal PIN-domain proteins and 5' nucleases. The structural properties of the PIN domain indicate its putative active center consisting of invariant acidic amino acid residues, which is geometrically similar to the active center of 5' nucleases and an archaeal PAE2754 PIN-domain protein associated with exonuclease activity.
Crystal structure of the PIN domain of human telomerase-associated protein EST1A.,Takeshita D, Zenno S, Lee WC, Saigo K, Tanokura M Proteins. 2007 Sep 1;68(4):980-9. PMID:17557331[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Takeshita D, Zenno S, Lee WC, Saigo K, Tanokura M. Crystal structure of the PIN domain of human telomerase-associated protein EST1A. Proteins. 2007 Sep 1;68(4):980-9. PMID:17557331 doi:10.1002/prot.21351
