Publication Abstract from PubMed
Nisin is a posttranslationally modified antimicrobial peptide that is widely used as a food preservative. It contains five cyclic thioethers of varying sizes that are installed by a single enzyme, NisC. Reported here are the in vitro reconstitution of the cyclization process and the x-ray crystal structure of the NisC enzyme. The structure reveals similarities in fold and substrate activation with mammalian farnesyl transferases, suggesting that human homologs of NisC posttranslationally modify a cysteine of a protein substrate.
Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis.,Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK Science. 2006 Mar 10;311(5766):1464-7. PMID:16527981[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
