1ice

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Image:1ice.jpg


PDB ID 1ice

Drag the structure with the mouse to rotate
, resolution 2.60Å
Ligands:
Activity: Caspase-1, with EC number 3.4.22.36
Coordinates: save as pdb, mmCIF, xml



STRUCTURE AND MECHANISM OF INTERLEUKIN-1BETA CONVERTING ENZYME


Overview

Interleukin-1 beta converting enzyme (ICE) processes an inactive precursor to the proinflammatory cytokine, interleukin-1 beta, and may regulate programmed cell death in neuronal cells. The high-resolution structure of human ICE in complex with an inhibitor has been determined by X-ray diffraction. The structure confirms the relationship between human ICE and cell-death proteins in other organisms. The active site spans both the 10 and 20K subunits, which associate to form a tetramer, suggesting a mechanism for ICE autoactivation.

About this Structure

1ICE is a Single protein structure of sequence from [1]. The following page contains interesting information on the relation of 1ICE with [Caspases]. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of interleukin-1 beta converting enzyme., Wilson KP, Black JA, Thomson JA, Kim EE, Griffith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA, et al., Nature. 1994 Jul 28;370(6487):270-5. PMID:8035875

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