Publication Abstract from PubMed
An early SAR study of a screening hit series has generated a series of 9-benzyl purines as inhibitors of bacterial glutamate racemase (MurI) with micromolar enzyme potency and improved physical properties. X-ray co-crystal EI structures were obtained.
Exploring 9-benzyl purines as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria.,Geng B, Breault G, Comita-Prevoir J, Petrichko R, Eyermann C, Lundqvist T, Doig P, Gorseth E, Noonan B Bioorg Med Chem Lett. 2008 Aug 1;18(15):4368-72. Epub 2008 Jun 24. PMID:18614367[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
