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Coordinated variations in the sequence of the Rev-binding element of HIV-1, identified by in vitro genetic selections, have been used as distance and conformational constraints for molecular modelling. Three-dimensional models of the wild-type Rev-binding element and several, evolved RNA ligands (aptamers) have been constructed. These models demonstrate that non-Watson-Crick pairings open the major groove allowing access of an alpha-helical peptide from Rev, and explain why some selected RNA sequences can bind Rev more tightly than others.
A three-dimensional model of the Rev-binding element of HIV-1 derived from analyses of aptamers.,Leclerc F, Cedergren R, Ellington AD Nat Struct Biol. 1994 May;1(5):293-300. PMID:7664035[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Leclerc F, Cedergren R, Ellington AD. A three-dimensional model of the Rev-binding element of HIV-1 derived from analyses of aptamers. Nat Struct Biol. 1994 May;1(5):293-300. PMID:7664035
