| Structural highlights
2xcp is a 6 chain structure with sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | ,
| | NonStd Res: | , |
| Related: | 1s0m, 2asl, 2jeg, 1rys, 2v4s, 2j6t, 2w9b, 1n56, 2atl, 1jx4, 2c22, 2va2, 1s97, 2agq, 2jej, 2w9c, 2ago, 2asj, 2asd, 2w9a, 1jxl, 1n48, 2bq3, 2j6u, 2uvu, 2agp, 2c2r, 1s0n, 2xc9, 2jef, 1s0o, 2w8l, 2uvw, 2bqr, 2jei, 2au0, 1s9f, 2bqu, 2xca, 2c28, 2v9w, 2v4r, 2c2e, 1ryr, 2uvv, 2c2d, 2v4q, 1s10, 2br0, 2j6s, 2uvr, 2va3, 2w8k, 2v4t |
| Gene: | DPO4 (Sulfolobus solfataricus) |
| Activity: | DNA-directed DNA polymerase, with EC number 2.7.7.7 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Crystal structures of a binary Mg2+-form Dpo4-DNA complex with 1,N2-etheno-dG in the template strand as well as of ternary Mg2+-form Dpo4-DNA-dCTP/dGTP complexes with 8-oxoG in the template strand have been determined. Comparison of their conformations and active-site geometries with those of the corresponding Ca2+-form complexes revealed that the DNA and polymerase undergo subtle changes as a result of the catalytically more active Mg2+ occupying both the A and B sites.
Metal-ion dependence of the active-site conformation of the translesion DNA polymerase Dpo4 from Sulfolobus solfataricus.,Irimia A, Loukachevitch LV, Eoff RL, Guengerich FP, Egli M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 1;66(Pt, 9):1013-8. Epub 2010 Aug 21. PMID:20823515[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Irimia A, Loukachevitch LV, Eoff RL, Guengerich FP, Egli M. Metal-ion dependence of the active-site conformation of the translesion DNA polymerase Dpo4 from Sulfolobus solfataricus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 1;66(Pt, 9):1013-8. Epub 2010 Aug 21. PMID:20823515 doi:10.1107/S1744309110029374
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