Publication Abstract from PubMed
Complexes of Arthrobacter globiformis amine oxidase (AGAO) with the inhibitors benzylhydrazine and tranylcypromine (an antidepressant drug) have been refined at 1.86 and 1.65 A resolution, respectively. Both inhibitors form covalent adducts with the TPQ cofactor. A tyrosine residue, proposed to act as a gate to the AGAO active site, is in its open conformation.
Complexes of the copper-containing amine oxidase from Arthrobacter globiformis with the inhibitors benzylhydrazine and tranylcypromine.,Langley DB, Trambaiolo DM, Duff AP, Dooley DM, Freeman HC, Guss JM Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jul 1;64(Pt, 7):577-83. Epub 2008 Jun 11. PMID:18607080[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
