2bgo
From Proteopedia
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MANNAN BINDING MODULE FROM MAN5C
Overview
Enzymes that digest plant cell wall polysaccharides generally contain, non-catalytic, carbohydrate-binding modules (CBMs) that function by, attaching the enzyme to the substrate, potentiating catalytic activity., Here, we present the first structure of a family 35 CBM, derived from the, Cellvibrio japonicus beta-1,4-mannanase Man5C. The NMR structure has been, determined for both the free protein and the protein bound to, mannopentaose. The data show that the protein displays a typical, beta-jelly-roll fold. Ligand binding is not located on the concave surface, of the protein, as occurs in many CBMs that display the jelly-roll fold, but is formed by the loops that link the two beta-sheets of the protein, similar to family 6 CBMs. In contrast to the majority of CBMs, which are, generally ... [(full description)]
About this Structure
2BGO is a [Single protein] structure of sequence from [Cellvibrio japonicus]. Full crystallographic information is available from [OCA].
Reference
Structure of a mannan-specific family 35 carbohydrate-binding module: evidence for significant conformational changes upon ligand binding., Tunnicliffe RB, Bolam DN, Pell G, Gilbert HJ, Williamson MP, J Mol Biol. 2005 Mar 25;347(2):287-96. PMID:15740741
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