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2lfb

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2lfb

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HOMEODOMAIN FROM RAT LIVER LFB1/HNF1 TRANSCRIPTION FACTOR, NMR, 20 STRUCTURES

Overview

The nuclear magnetic resonance (NMR) solution structure of the, non-classical homeodomain from the rat liver LFB1/HNF1 transcription, factor was determined with the program DIANA from an input of 1356 nuclear, Overhauser enhancement (NOE) upper distance constraints and 228 dihedral, angle constraints collected using experiments with the unlabelled, the, uniformly 15N-labelled and the uniformly 13C-labelled protein. Out of a, group of 50 independently calculated conformers the 20 conformers with the, smallest residual DIANA target function values were refined by energy, minimization with the program OPAL and are used to represent the NMR, structure. The average of the pairwise root-mean-square deviations, (r.m.s.d.) of these 20 individual NMR conformers relative to the mean, coordinates is ... [(full description)]

About this Structure

2LFB is a [Single protein] structure of sequence from [Rattus rattus]. Structure known Active Site: S1. Full crystallographic information is available from [OCA].

Reference

The NMR solution structure of the non-classical homeodomain from the rat liver LFB1/HNF1 transcription factor., Schott O, Billeter M, Leiting B, Wider G, Wuthrich K, J Mol Biol. 1997 Apr 4;267(3):673-83. PMID:9126845

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