1jnx

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spinqualitylabelsall models PDB ID 1jnx Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
, resolution 2.5Å
Ligands:
Gene:	BRCA1 (Homo sapiens)
Coordinates:	save as pdb, mmCIF, xml

Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The C-terminal BRCT region of BRCA1 is essential for its DNA repair, transcriptional regulation and tumor suppressor functions. Here we determine the crystal structure of the BRCT domain of human BRCA1 at 2.5 A resolution. The domain contains two BRCT repeats that adopt similar structures and are packed together in a head-to-tail arrangement. Cancer-causing missense mutations occur at the interface between the two repeats and destabilize the structure. The manner by which the two BRCT repeats interact in BRCA1 may represent a general mode of interaction between homologous domains within proteins that interact to regulate the cellular response to DNA damage. The structure provides a basis to predict the structural consequences of uncharacterized BRCA1 mutations.

Disease

Known diseases associated with this structure: Breast cancer-1 OMIM:[113705], Breast-ovarian cancer OMIM:[113705], Ovarian cancer OMIM:[113705], Papillary serous carcinoma of the peritoneum OMIM:[113705]

About this Structure

1JNX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1., Williams RS, Green R, Glover JN, Nat Struct Biol. 2001 Oct;8(10):838-42. PMID:11573086

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