Structural highlights
Publication Abstract from PubMed
Glucagon-like peptide-2 (GLP-2) is a therapeutic target used in the treatment of short bowel syndrome. In this paper, we present the three dimensional solution structure of GLP-2 peptide determined using nuclear magnetic resonance (NMR) and molecular modelling. The GLP-2 adopts an alpha-helical conformation similar to that of secretin family of hormones. In order to understand the molecular details governing the ligand binding and receptor activation, macromolecular docking studies were performed between the N-terminal extracellular domain of GLP-2 receptor and the GLP-2 hormone using a data driven docking program.
Conformational and molecular interaction studies of glucagon-like peptide-2 with its N-terminal extracellular receptor domain.,Venneti KC, Hewage CM FEBS Lett. 2011 Jan 21;585(2):346-52. Epub 2010 Dec 15. PMID:21167157[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Venneti KC, Hewage CM. Conformational and molecular interaction studies of glucagon-like peptide-2 with its N-terminal extracellular receptor domain. FEBS Lett. 2011 Jan 21;585(2):346-52. Epub 2010 Dec 15. PMID:21167157 doi:10.1016/j.febslet.2010.12.011
