1k9j

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spinqualitylabelsall models PDB ID 1k9j Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
, resolution 1.90Å
Ligands:
Coordinates:	save as pdb, mmCIF, xml

Complex of DC-SIGNR and GlcNAc2Man3

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Dendritic cell specific intracellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC-SIGN), a C-type lectin present on the surface of dendritic cells, mediates the initial interaction of dendritic cells with T cells by binding to ICAM-3. DC-SIGN and DC-SIGNR, a related receptor found on the endothelium of liver sinusoids, placental capillaries, and lymph nodes, bind to oligosaccharides that are present on the envelope of human immunodeficiency virus (HIV), an interaction that strongly promotes viral infection of T cells. Crystal structures of carbohydrate-recognition domains of DC-SIGN and of DC-SIGNR bound to oligosaccharide, in combination with binding studies, reveal that these receptors selectively recognize endogenous high-mannose oligosaccharides and may represent a new avenue for developing HIV prophylactics.

Disease

Known disease associated with this structure: SARS infection, protection against OMIM:[605872]

About this Structure

1K9J is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR., Feinberg H, Mitchell DA, Drickamer K, Weis WI, Science. 2001 Dec 7;294(5549):2163-6. PMID:11739956

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