5'-deoxy-5'-methylthioadenosine phosphorylase

From Proteopedia

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spinqualitylabelsall models Structure of human MTAP complex with MTA (PDB code 1cg6). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function 5’-deoxy-5’-methylthioadenosine phosphorylase (MTAP) catalyzes the reversible phosphorolysis of 5’-deoxy-5’-methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1-phosphate. This reaction is the principle source of adenine in human cells. Disease Relevance MTAP is a potential target of chemotherapy. More than 20% of human various cancer cells do not show MTAP activity. Structural highlights

3D structures of 5’-deoxy-5’-methylthioadenosine phosphorylase (Updated on 11-November-2014)

• MTAP

• • 3oze – hMTAP - human
    
  • 4glf – ubMTAP – uncultured bacteria
    
  • 4l5y – SmMTAP – Schistosoma mansoni
    

• MTAP complex with adenine

• • 1cb0 – hMTAP (mutant) + adenine
    
  • 1wta – MTAP + adenine – Aeropyrum pernix
    
  • 4l5c, 4l6i – SmMTAP + adenine
    

• MTAP complex with MTA

• • 1cg6 – hMTAP (mutant) + MTA
    
  • 2a8y, 3t94 – MTAP + MTA – Sulfolobus solfataricus
    

• MTAP complex with antibiotics

• • 1sd1, 1sd2 – hMTAP + antibiotic
    
  • 4l5a – SmMTAP + antibiotic
    

• MTAP other complexes

• • 3ozc, 3ozd – hMTAP + pCL-phenylthioDADMeImmA
    
  • 4glj – ubMTAP + rhodamine
    
  • 1k27 – hMTAP + transition state analog
    

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References