Function
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) is a prokaryotic enzyme which is part of the folate synthesis pathway. HPPK catalyzes the attachment of pyrophosphate to 6-hydroxymethyl-7,8-dihydropterin to form
6-hydroxymethyl-7,8-dihydropteridine pyrophosphate. HPPK is inhibited by a variety of antimicrobial agents like trimethoprim and sulfonamides.
Disease
Relevance
Structural highlights