7,8-diaminopelargonic acid synthase

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spinqualitylabelsall models Structure of E. coli 7,8-diaminopelargonic acid synthetase complex with PLP, KAPA and Na+ ion (purple) (PDB code 1qj3). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function 7,8-diaminopelargonic acid synthetase (DAPAS) is part of the biotin biosynthesis pathway. DAPAS catalyzes the amino transfer from S-adenosylmethionine to 7-keto-8-pelargonic acid (KAPA) to produce S-adenosyl-4-methylthio-2-oxobutanoate and 7,8-diaminopelargonic acid. DAPAS is a pyridoxal phosphate (PLP)-dependent enzyme. Bifunctional DAPAS/dethiobiotin synthetase (DAPS/DTBS) catalyzes the above reaction and the conversion of 7,8-diaminonanoate, ATP and CO2 to ADP, phosphate and dethiobiotin. Disease Relevance Structural highlights

3D Structures of 7,8-diaminopelargonic acid synthetase (Updated on 11-November-2014)

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• 7,8-diaminopelargonic acid synthetase

• • 1dty, 1qj5 – EcDAPAS + PLP - Escherichia coli
    
  • 1mgv, 1s07 – EcDAPAS (mutant) + PLP
    
  • 3bv0 – MtDAPAS (mutant) + PLP – Mycobacterium tuberculosis
    
  • 3dod – BsDAPAS + PLP – Bacillus subtilis
    
  • 3drd – BsDAPAS + PLP
    
  • 1s06, 1s08, 1s09, 1s0a – EcDAPAS (mutant) + PLP derivative
    
  • 4a0g – AtDAPAS + PLP – Arabidopsis thaliana
    
  • 4a0f – AtDAPAS (mutant) + PLP
    

• 7,8-diaminopelargonic acid synthetase complex

• • 1qj3 – EcDAPAS + PLP + KAPA
    
  • 1mly, 1mlz – EcDAPAS + PLP + amiclenomycin
    
  • 3du4 – BsDAPAS + PLP + KAPA
    
  • 4a0h – AtDAPAS + PLP + KAPA
    
  • 4cxq – MtDAPAS + PLP + KAPA
    
  • 3lv2 – MtDAPAS + PLP + sinefungin
    
  • 3tft, 3tfu – MtDAPAS + PLP + inhibitor
    
  • 4mqp, 4mqq, 4mqr – MtDAPAS + inhibitor
    

• Bifunctional 7,8-diaminopelargonic acid synthetase/dethiobiotin synthetase

• • 4a0f, 4a0g – AtDAPAS + PLP
    
  • 4a0r – AtDAPAS + PLP + dethiobiotin
    
  • 4a0h – AtDAPAS + PLP + keto-aminopelargonic acid
    

References