A Disintegrin And Metalloproteinase

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Image:2ao7.png
Crystal structure of A Disintegrin And Metalloproteinase 2ao7

Template:STRUCTURE 2ao7

















A Disintegrin And Metalloproteinase (ADAM) are peptidases which cleave off extracellular portions of transmembrane proteins. ADAM inhibitors are used in anti-cancer therapy. ADAM family members are numbered. ADAM10 cleaves ephrin. ADAM13 details in Molecular Playground/ADAM13. ADAM17 (TACE) processes the tumor necrosis factor-α. ADAM33 is implicated in asthma. ADAMTS is ADAM with thrombospondin motifs. ADAMTS1 has anti-angionenic activity. ADAMTS4 and ADAMTS5 are involved in the degradation of aggrecan. ADAMTS13 cleaves von Willebrand factor involved in blood clotting. The images at the left and at the right correspond to one representative ADAM, i.e. the crystal structure of bovine A Disintegrin And Metalloproteinase 10 (2ao7).







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3D Structures of A Disintegrin And Metalloproteinase

Updated on 11-November-2014

2fv5, 2fv9, 2i47, 3b92, 3cki, 3e8r, 3edz, 3ewj, 3g42, 3l0t, 3l0v, 3le9, 3lea, 3lgp, 3kmc, 3kme, 3o64, 2oi0 - hADAM17 catalytic domain (mutant)+ inhibitor

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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