Molecular Playground/Streptavidin

In the Schiffman Lab, we fabricate many types of soft materials including electrospun nanofibers, hydrogels, and nanoparticles. In order to tailor each material for wound management and health care applications, it is necessary to functionalize each material with polymers, enzymes, growth factors or antibiotics. To attach such molecules, we attach streptavidin to our material and take advantage of the streptavidin/biotin bond to add agents such as biotinylated antibodies. Biotin can attach to any of the four subunits of streptavidin. The of biotin in the complex shows where biotin can bind to streptavidin. The

  comprise part of the biotin-binding site of the streptavidin molecule.