Molecular Playground/IntegrinBeta1

From Proteopedia

proteopedia linkproteopedia link

One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground. Molecular Playground banner: "

Banner: Integrin Beta 1 binds to ECM proteins and allows for 3D in vitro cell migration

spinqualitylabelsall models Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Contents 1 Structure 2 Function 3 Disease 4 Studying Integrin Beta-1 in vitro 5 Peyton Lab Research Interests 6 References

Structure

Here are the

Function

Integrins are a class of surface proteins that bind to extra cellular matrix components and transmit chemical and mechanical cues to internal signaling pathways. Integrin beta 1 binds many proteins when dimerized with an alpha subunit, including collagen, laminin and fibronectin.

Disease

Studying Integrin Beta-1 in vitro

Peyton Lab Research Interests

The Peyton lab studies how cells process chemical and physical cues from the extracellular matrix and how these interactions play a role the progression of cardiovascular disease and cancer. We aim to understand the downstream signaling pathways activated when cells use their integrins to bind to matrix and how this translates to the disease of interest.

References