Function
Complement factor H (CFH) regulates the complement system which is part of the immune response. CFH protects cells by preventing the activation of the complement system when it is not needed. CFH contains 20 short consensus repeats (sushi domains).
Disease
CFH mutations are involved in dense deposit disease, age-related macular degeneration, atypical hemolytic-uremic syndrome and the kidney disorder glomerulonephritis.
Relevance
Structural highlights
3D structures of complement factor H
Updated on 20-November-2014
References