Structure of mouse cyclic GMP-AMP synthase C terminal complex with DNA, ATP, Mg+2 (green) and Zn+2 (grey) ions (PDB code 4k97).
Cyclic GMP-AMP synthase (CGAS) binds to DNA and catalyzes cGAMP synthesis. The cGAMP activates the type-I interferon pathway.
Mice lacking CGAS are more vulnerable to lethal infection by DNA virus.
Updated on 20-November-2014
Michal Harel, Alexander Berchansky, Joel L. Sussman
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