From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 1mzf

For details on Factor inhibiting HIF see Molecular Playground/FIH. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen.

3D Structures of factor inhibiting HIF

Updated on 24-November-2014 {{#tree:id=OrganizedByTopic|openlevels=0|

• FIH1α

• • 1mze, 1h2n, 1iz3 – hFIH1α – human

• FIH1α complex with small molecule

• • 1yci, 3od4, 2yc0, [[2yde] – hFIH1α + inhibitor
    
  • 2w0x - hFIH1α + pyridine derivative
    
  • 2cgn – hFIH1α + succinate
    
  • 2cgo – hFIH1α + fumarate
    
  • 1mzf, 2wa3, 2wa4, 2yc0, 2yde – hFIH1α + oxoglutarate derivative
    
  • 3kcx, 3kcy, 3od4, 4bio - hFIH1α + quinol derivative
    
  • 4ai8 - hFIH1α + daminozide
    

• FIH1α complex with polypeptide

• • 1h2k, 1h2l, 1h2m – hFIH1α + HIF transactivation domain peptide
    
  • 2ilm, 3d8c - hFIH1α (mutant) + HIF peptide + α-ketoglutarate
    
  • 3p3n, 3p3p - hFIH1α + Notch 1 peptide
    
  • 2xum - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative
    
  • 2y0i - hFIH1α + tankyrase 2 peptide
    
  • 3hqr, 3hqu - hFIH 1α C terminal + EGL nine homolog
    
  • 1lqb, 1lm8 - hFIH 1α residues 549-582 + elongin B + elongin C + PVHL
    
  • 1l3e - hFIH 1α C terminal + P300 Cys/His-rich domain – NMR
    
  • 1l8c - hFIH 1α C terminal + CREB-binding protein zinc finger
    
  • 4h6j - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator
    
  • 4b7e, 4b7k, 4jaa - hFIH1α + consensus ankyrin repeat peptide
    

• FIH2α

• • 2a24, 3f1n, 3f1o, 3f1p, 3h7w - hFIH 2α PAS domain + hFIH 1β PAS domain
    
  • 3h82 - hFIH 2α PAS domain (mutant) + hFIH 1β PAS domain (mutant)

• FIH1β

• • 2b02, 1x0o - hFIH 1β PAS domain
    
  • 2hv1, 2k7s - hFIH 1β PAS domain - NMR

}}