Glutaminase

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Template:STRUCTURE 3unw

Glutaminase (GLN) catalyzes the conversion of glutamine (Gln) to glutamic acid (Glu). GLN is present at the axonal termini of neurons where GA functions as a neurotransmitter. ADP is an activator of GLN. GLN is a homodimer. In human GLN is found as 2 isozymes – GLN and GLN 2. Glutaminase-asparaginase (GLN-ASN) can amidohydrolase both glutamine and asparagine to their corresponding Glu and Asp.

3D structures of glutaminase

Updated on 26-November-2014 {{#tree:id=OrganizedByTopic|openlevels=0|

• GLN

• • 3if5, 3ih8, 3ih9, 3agd – MlGLN – Micrococcus luteus
    
  • 2pby – GLN – Geobacillus kaustophilus
    
  • 2zk9 – CpGLN – Chryseobacterium proteolyticum
    
  • 3a54, 3a55, 3a56 – CpGLN (mutant)
    
  • 3agf - BsGLN – Bacillus subtilis
    
  • 3ss3, 3ss4 – mGLN C – mouse
    
  • 4jkt - mGLN kidney isoform
    
  • 3voy – hGLN kidney isoform – human
    
  • 4bqm - hGLN liver isoform
    

• GLN complex

• • 3brm – BsGLN + norleucine
    
  • 3czd, 3unw – hGLN + Glu
    
  • 3vp0 – hGLN + Gln
    
  • 3uo9, 3voz, 3vp2, 3vp3, 3vp4 - hGLN + inhibitor
    
  • 3iha, 3ihb, 3age - MlGLN + Glu
    
  • 3ss5 – mGLN + Glu
    
  • 3vp1 - hGLN + inhibitor + Glu
    

• GLN-ASN

• • 1agx – GLN-ASN – Acinetobacter glutaminacificans
    
  • 3pga, 4pga – PsGLN-ASN – Pseudomonas
    
  • 1djo, 1djp - PsGLN-ASN + norvaline derivative
    

• Other GLN

• • 1u60 - YbaS
    
  • 3brm - YbgJ in a complex with DON
    
  • 1mki - YbgJ free
    

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Created with the participation of Lindsey Butler.