Function
Glycosylasparaginase or aspartylglucosaminidase (AGA) hydrolyzes a number of β-aspartyl amides including asparagine. AGA contains α and β subunits which derive from a precursor (PAGA) which is cleaved post-translationally. Mammalian AGA substrate is the protein-sugar bond of Asn-GlcNac.
Disease
AGA deficiency is the cause of the human lysosomal disease aspartylglycosaminuria.
Relevance
Structural highlights