Cas9

From Proteopedia

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Cas9 is the RNA-guided DNA endonuclease used by the CRISPR(clustered regularly interspaced short palindromic repeats)-associated systems to generate double-strand DNA breaks in the invading DNA during an adaptive bacterial immune response.

It has been exploited for use in genome editing systems.

Articles in Proteopedia concerning Cas9 include:

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Contents 1 3D structures of Cas9 1.1 Streptococcus pyogenes Cas9 1.2 Actinomyces naeslundii Cas9 2 See Also 3 References

3D structures of Cas9

Streptococcus pyogenes Cas9

• 4un3, 4un4, and 4un5 - S. pyogenes Cas9 bound to sgRNA and target DNA
• 4oo8 - - S. pyogenes Cas9 bound to sgRNA and target DNA
• 4cmp
• 4cmq - Mn²⁺-bound S. pyogenes Cas9

Actinomyces naeslundii Cas9

• 4oge
• 4ogc - Mn²⁺-bound A.s naeslundii Cas9

See Also

HNH endonuclease

References