Nitroreductase

From Proteopedia

Revision as of 12:26, 1 December 2014 by Michal Harel (Talk | contribs)

(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)

Nitroreductase (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO₂ group. The NO₂ group is reduced to hydroxylamine. NR use FMN as cofactor. Among NRs are the oxygen-insensitive NAD(P)H NR and NADH dehydrogenase. The NR is of special interest due to its potential use as activator of prodrugs in cancer therapy.