UreE is an essential metallochaeprone for Helicobacter pylori (H.pylori). H.pylori is a class I human pathogen that is involved in causing gastric ulcers and stomach cancers. Its two nickel dependent enzymes - Urease and NiFe-H2ase, provides it a unique ability to survive and colonize in acidic human stomach. Urease catalyzes the conversion of urea to ammonia and carbamate which neutralizes its local acidic environment.
Function
Several accessory proteins play a crucial role in the maturation of Urease. UreE is a urease-specific nickel metallochaperone that is involved in the delivery nickel to urease.
Structural highlights
Apo-UreE from H.pylori is a dimer. HpUreE can bind one Ni(II) per dimer . Nickel is bound to UreE in an octahedral fashion with one His from one subunit and two His from other subunit .In presence of Ni, its oligomeric state changes to a tetramer (dimer of dimer).
References
<http://www.ncbi.nlm.nih.gov/pubmed/20681615/>
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