1mey

From Proteopedia

Revision as of 10:42, 20 March 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:1mey.gif


PDB ID 1mey

Drag the structure with the mouse to rotate
, resolution 2.200Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF A DESIGNED ZINC FINGER PROTEIN BOUND TO DNA


Overview

Considerable recent effort has been devoted to the design and selection of sequence-specific DNA binding proteins based on tandem arrays of Cys2His2 zinc finger domains. While the DNA binding properties of these designed proteins have been studied extensively, the structural basis for site-specific binding has not been examined experimentally. Here we report the crystal structure of a complex between a protein comprised of three consensus-sequence-based zinc finger domains and an oligonucleotide corresponding to a favourable DNA binding site. This structure reveals relatively simple modular interactions and structural adaptations that compensate for differences in contact residue side-chain lengths.

About this Structure

1MEY is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

A 2.2 A resolution crystal structure of a designed zinc finger protein bound to DNA., Kim CA, Berg JM, Nat Struct Biol. 1996 Nov;3(11):940-5. PMID:8901872 [[Category: ]]

Page seeded by OCA on Thu Mar 20 12:42:38 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mey"
Personal tools