1mq0

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spinqualitylabelsall models PDB ID 1mq0 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
, resolution 2.40Å
Ligands:	and
Activity:	Cytidine deaminase, with EC number 3.5.4.5
Coordinates:	save as pdb, mmCIF, xml

Crystal Structure of Human Cytidine Deaminase

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Human cytidine deaminase (CDA) is an enzyme prominent for its role in catalyzing metabolic processing of nucleoside-type anticancer and antiviral agents. It is thus a promising target for the development of small molecule therapeutic adjuvants. We report the first crystal structure of human CDA as a complex with a tight-binding inhibitor, diazepinone riboside 1. The structure reveals that inhibitor 1 is able to establish a canonical pi/pi-interaction with a key active site residue, Phe 137.

Disease

Known disease associated with this structure: Anemia, congenital dyserythropoietic, type I OMIM:[607465]

About this Structure

1MQ0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human cytidine deaminase bound to a potent inhibitor., Chung SJ, Fromme JC, Verdine GL, J Med Chem. 2005 Feb 10;48(3):658-60. PMID:15689149

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