1ngt

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Image:1ngt.gif


PDB ID 1ngt

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, resolution 2.04Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



The Role of Minor Groove Functional Groups in DNA Hydration


Overview

Here we describe the crystal structure of modified [d(CGCGAATTCGCG)]2 refined to 2.04 A. The modification, which affects only the two thymines at the central ApT step, involves isosteric removal of the 2-keto oxygen atoms and substitution of the N1 nitrogen with carbon. The crystal structure reveals the ability of this modified thymine to effectively base pair with adenine in [d(CGCGAAtTCGCG)]2. The structure also suggests that the minor groove 'spine of hydration' is destabilized but essentially intact.

About this Structure

1NGT is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

The role of minor groove functional groups in DNA hydration., Woods KK, Lan T, McLaughlin LW, Williams LD, Nucleic Acids Res. 2003 Mar 1;31(5):1536-40. PMID:12595562

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