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1nuh

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Revision as of 11:01, 20 March 2008 by OCA (Talk | contribs)
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Image:1nuh.gif


PDB ID 1nuh

Drag the structure with the mouse to rotate
, resolution 2.51Å
Ligands: and
Gene: GPI (Homo sapiens)
Activity: Glucose-6-phosphate isomerase, with EC number 5.3.1.9
Coordinates: save as pdb, mmCIF, xml



The crystal structure of human phosphoglucose isomerase complexed with 5-phosphoarabinonate


Contents

Overview

Phosphoglucose isomerase (PGI) is a workhorse enzyme of carbohydrate metabolism that interconverts glucose 6-phosphate and fructose 6-phosphate. Outside the cell, however, the protein appears to function as a cytokine. A crystal structure of human PGI bound with 5-phosphoarabinonate, a strong inhibitor that mimics the cis-enediol(ate) intermediate of the reaction, has been determined at 2.5 A resolution. The structure helps to confirm the assignment of Glu357 as the base catalyst in the isomerase reaction.

Disease

Known diseases associated with this structure: Hemolytic anemia due to glucosephosphate isomerase deficiency OMIM:[172400], Hydrops fetalis, one form OMIM:[172400]

About this Structure

1NUH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of human phosphoglucose isomerase complexed with a transition-state analogue., Davies C, Muirhead H, Chirgwin J, Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):1111-3. Epub 2003, May 23. PMID:12777791

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