Function
UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) is a Zn-dependent protein which participates in the biosynthesis of lipid A. Lipid A anchors lipopolysaccharides into the membrane of Gram negative bacteria. LpxC catalyzes the conversion of UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetylglucosamine to UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-glucosamine.
Disease
Relevance
Structural highlights