Structural highlights
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
A series of substituted benzo[c][2,7]-naphthyridines were prepared and showed good potency in inhibiting PDK-1. The synthesis and SAR of this series of compounds are presented as well as the X-ray crystal structure of one of these analogs in a complex with PDK-1.
Benzo[c][2,7]naphthyridines as inhibitors of PDK-1.,Kim KH, Wissner A, Floyd MB Jr, Fraser HL, Wang YD, Dushin RG, Hu Y, Olland A, Guo B, Arndt K Bioorg Med Chem Lett. 2009 Sep 1;19(17):5225-8. Epub 2009 Jul 8. PMID:19628388[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Kim KH, Wissner A, Floyd MB Jr, Fraser HL, Wang YD, Dushin RG, Hu Y, Olland A, Guo B, Arndt K. Benzo[c][2,7]naphthyridines as inhibitors of PDK-1. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5225-8. Epub 2009 Jul 8. PMID:19628388 doi:10.1016/j.bmcl.2009.07.007
