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Variable lymphocyte receptor

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Variable lymphocyte receptor of lamprey (grey) bound to a protein antigen (green) (3g3a), resolution 2.20Å

Drag the structure with the mouse to rotate

Variable lymphocyte receptors (VLRs) are leucine-rich repeat (LRR) family proteins that mediate adaptive immune responses in the jawless vertebrates, lampreys and hagfish. ^[1]

Lamprey Variable Lymphocyte Receptor in complex with a protein antigen (3g3a)

1 See Also
2 3D structures of variable lymphocyte receptor
3 Additional Literature
4 References

3D structures of variable lymphocyte receptor

Updated on 18-December-2014

3m19, 3g39, 2r9u, 3wo9, 4k5u, 4k79 - mlVLR ectodomain – marine lamprey

3m18, 3g3a – mlVLR ectodomain + lysozyme
3g3b - mlVLR ectodomain (mutant) + lysozyme
3e6j - mlVLR ectodomain + trisaccharide
2o6q, 2o6r, 2o6s – IhVLR leucine-rich repeat – inshore hagfish
2z62, 2z63, 2z66 – IhVLR/hTLR4
3ul7, 3ul8, 3ul9 – IhVLR/hTLR4 (mutant)
3ula – IhVLR/hTLR4 (mutant) + eritoran
2z80, 2z81, 2z82, 3a78, 3a7c – IhVLR/hTLR2
2z65 – IhVLR/hTLR4 + lymphocyte antigen 96
2z7x – IhVLR/hTLR1 + IhVLR/hTLR2 + tri-acylated lipopeptide
3a79 - IhVLR/hTLR2 + IhVLR/hTLR6 + tri-acylated lipopeptide
3twi – VLR B antigen-binding domain + BCLA protein – Bacillus anthracis
Articles in Proteopedia concerning Variable lymphocyte receptors include:

Lamprey Variable Lymphocyte Receptor

Additional Literature

Bajoghli B, Guo P, Aghaallaei N, Hirano M, Strohmeier C, McCurley N, Bockman DE, Schorpp M, Cooper MD, Boehm T. A thymus candidate in lampreys. Nature. 2011 Feb 3;470(7332):90-4. PMID:21293377 doi:10.1038/nature09655
Herrin BR, Cooper MD. Alternative adaptive immunity in jawless vertebrates. J Immunol. 2010 Aug 1;185(3):1367-74. PMID:20660361 doi:10.4049/jimmunol.0903128
Mariuzza RA, Velikovsky CA, Deng L, Xu G, Pancer Z. Structural insights into the evolution of the adaptive immune system: the variable lymphocyte receptors of jawless vertebrates. Biol Chem. 2010 Jul;391(7):753-60. PMID:20482318 doi:10.1515/BC.2010.091
Velikovsky CA, Deng L, Tasumi S, Iyer LM, Kerzic MC, Aravind L, Pancer Z, Mariuzza RA. Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen. Nat Struct Mol Biol. 2009 Jul;16(7):725-30. Epub 2009 Jun 21. PMID:19543291 doi:10.1038/nsmb.1619
Herrin BR, Cooper MD. Alternative adaptive immunity in jawless vertebrates. J Immunol. 2010 Aug 1;185(3):1367-74. PMID:20660361 doi:10.4049/jimmunol.0903128
Herrin BR, Alder MN, Roux KH, Sina C, Ehrhardt GR, Boydston JA, Turnbough CL Jr, Cooper MD. Structure and specificity of lamprey monoclonal antibodies. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2040-5. Epub 2008 Jan 31. PMID:18238899 doi:10.1073/pnas.0711619105
Han BW, Herrin BR, Cooper MD, Wilson IA. Antigen recognition by variable lymphocyte receptors. Science. 2008 Sep 26;321(5897):1834-7. PMID:18818359 doi:321/5897/1834

See Lamprey Variable Lymphocyte Receptor for details.

References

↑ Kim HM, Oh SC, Lim KJ, Kasamatsu J, Heo JY, Park BS, Lee H, Yoo OJ, Kasahara M, Lee JO. Structural diversity of the hagfish variable lymphocyte receptors. J Biol Chem. 2007 Mar 2;282(9):6726-32. Epub 2006 Dec 27. PMID:17192264 doi:10.1074/jbc.M608471200