1q6k
From Proteopedia
| |||||||
| , resolution 2.1Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Gene: | CTSK OR CTSO (Homo sapiens) | ||||||
| Activity: | Cathepsin K, with EC number 3.4.22.38 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate
Contents |
Overview
The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S(1) subsite with a series of alpha-amino aldehyde derivatives substituted at the P(1) position afforded compounds with cathepsin K IC(50)s between 52 microM and 15 nM.
Disease
Known disease associated with this structure: Pycnodysostosis OMIM:[601105]
About this Structure
1Q6K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Exploration of the P1 SAR of aldehyde cathepsin K inhibitors., Catalano JG, Deaton DN, Furfine ES, Hassell AM, McFadyen RB, Miller AB, Miller LR, Shewchuk LM, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2004 Jan 5;14(1):275-8. PMID:14684342
Page seeded by OCA on Thu Mar 20 13:33:37 2008
Categories: Cathepsin K | Homo sapiens | Single protein | Catalano, J G. | Deaton, D N. | Furfine, E S. | Hassell, A M. | McFadyen, R B. | Miller, A B. | Miller, L R. | Shewchuk, L M. | Willard, D H. | Wright, L L. | SO4 | TCO | Cathepsin k | Catk
